Cleaning PC Hardware on the Outside ...

Always turn off and unplug the system before you clean any of its components. Never apply any liquid directly to a pc component. Apply the liquid on a clean soft cloth, and wipe the computer with the cloth.
Clean the case: Wipe the computer case and clear its ventilation ports of any obstructions. Compressed air or a good paint brush is great for this, but don't blow dust into the PC or its optical and floppy drives.
Mechanical mouse: When a mechanical mouse gets dirty, the pointer moves erratically. Unscrew the ring on the bottom of the unit and remove the ball. Then scrape the accumulated gunk off the two plastic rollers that are set 90 degrees apart.
Keyboard: Turn the keyboard upside down and shake it to clear the crumbs from between the keys. If that doesn't work, blast it briefly with compressed air. If your keys stick or your keyboard is really dirty, remove the keys for easier cleaning. You can pop them off by using two pencils as jumbo tweezers, just be sure to use a soft touch.
Monitor: Wipe the monitor case and clear its vents of obstructions, without pushing dust into the unit. Clean the screen with a standard glass cleaner and a clean soft cloth. Many LCD screens can be cleaned with isopropyl alcohol; check with your LCD manufacturer. Wipe your LCD lightly as the underlying glass is fragile.
CD and DVD media: Gently wipe each disc with a moistened soft cloth. Use a motion that starts at the center of the disc and then moves outward toward the edge of the disk. Never wipe a disc in a circular motion.